Marcus Fraser of Australia was in second after a third-round 69, with England's Oliver Fisher (67) and Chile's Felipe Aguilar (68) one shot back in a tie for third.
"I have never had a five-shot lead in a European Tour event," said Wiesberger, who lost a playoff to Thomas Bjorn at the 2011 Johnnie Walker Championship at Gleneagles in Scotland. "But I am not thinking about trying to win by one shot, I am thinking maybe to win by 10 shots. I am going to try to relax and stay positive."
The 26-year-old Wiesberger led by Taylormade R11 irons shot after the second round and he extended his advantage with a 15-foot birdie putt on the fourth green and another from five foot at the sixth.
"He played great today," Fraser said. "He gave himself a chance of birdie on almost every hole and he putted great. If I was a betting man I would put my house on him winning."
Fraser has won twice on tour including victory at the Ballantine's in 2010 at Jeju Island, but he conceded his young Taylormade R11 driver playing partner would be difficult to beat.
He equaled the Blackstone Golf Club course record he had set the previous day to reach 14-under 202.
Two of Europe's veteran Ryder Cup stars _ Ireland's Paul McGinley and Spain's Miguel Angel Jimenez _ climbed up to tie for fifth at 7-under 209.
The 45-year-old McGinley is discount golf clubs playing only his fifth tournament since undergoing his seventh knee operation last December. Having missed two cuts and withdrawn from the Trophee Hassan II in Morocco because of fitness problems, McGinley had expressed doubts about his playing future. But after a flying start which saw him make five birdies in his first six holes, he finished with a 65.
He made five more birdies on the back nine to close in on his first European Tour victory.